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Z704008
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Applying Genomic and Proteomic Microarray Technology in Drug Discovery
| ISBN-10: | 0-84931469-0 |
| ISBN-13: | 978-0-84931469-8 |
Description
| General description | The book covers the issues surrounding gene expression and protein microarrays for pharmacogenomic and pharmacoproteomic applications. The author critically assesses those studies that have helped define applications in genomics and proteomics, explains gene expression microarray applications, and examines the utility of the protein microarray. He covers alternative substrates and the preparation of various surface chemistries together with their suitability for immobilization of nucleic acids and proteins. He delineates the mechanics of microarraying including environmental conditions, printer and pin performance. The book supplies protocols for printing nucleic acids and proteins and a discussion of other important parameters such as print buffers (inks) and factors influencing print quality. |
Properties
| publication info | R. Matson, CRC Press, 2005, 243 pp., hard cover |
Table Of Contents
| Table of Contents | QUANTITATIVE BIOLOGY: THE "OMICS" ERA Introduction Microarray Format General Utility The Omic Era Role of Gene Expression Microarrays in Drug Discovery Proteomics Today: The Great Challenge Potential Role for Protein Microarrays in Drug Discovery Critical Issues with Protein Microarrays Future medicine: Pharmacoproteomics or pharmacogenomics? References COMMERCIAL MICROARRAYS Introduction In situ arrays Ex situ or spotted arrays 3D and 4D chips Flow-Through biochips note: flow-through is a general term when applied here, remove TM. This should have also been corrected in the book proofs. Electronic biochips Future opportunities References SUPPORTS AND SURFACE CHEMISTRIES Introduction Substrates Summary References ARRAYING PROCESSES Introduction Creating spotted microarrays Printing parameters Protocols for printing nucleic acids Protocols for printing proteins References GENE EXPRESSION: MICROARRAY-BASED APPLICATIONS Introduction Applications demonstrating DNA microarray utility Biomedical research applications References PROTEIN MICROARRAY APPLICATIONS Introduction Spot theory Applications demonstrating protein microarray utility Measuring microarray performance Other microarray formats useful for proteomic applications References Index |
